The group is engaged in the development of advanced methods of vibrational spectroscopy and microspectroscopy, with an emphasis on overcoming the current limits of vibrational spectroscopic techniques (e.g. lowering the detection limit, nanoscale resolution, system stability). We focus mainly on surface-enhanced methods, namely surface-enhanced Raman scattering (SERS) and surface-enhanced infrared absorption (SEIRA). The basic principle of these techniques is the amplification of the spectral signal of analytes due to the interaction of analytes with electromagnetic radiation on nano- / micro-structured plasmon amplifiers (coinage metal-based substrates).
Currently, the research aims primarily at the use of conventional and surface-enhanced spectroscopic techniques for trace analysis and identification of drugs, natural compounds derived from plant material (with the focus on secondary metabolites), addictive alkaloids, and corrosion products on metal surfaces.
Various real and model systems are studied to elucidate the properties of cell membranes, skin components and layers in terms of barrier and permeation properties, which affect the bioavailability of topical and transdermal medicinal products, respectively.
Head: |
Prof. Vladimír Setnička |
Members: |
Martin Člupek, Ph.D. Vadim Prokopec, Ph.D Ing. Marie Švecová, Ph.D. |
PhD students: |
Michaela Gráfová, M.Sc. (PM)* Zuzana Němečková, M.Sc. (PŘ) Veronika Skoupá, M.Sc. (VS) Lucia Becherová M.Sc. (PM) |
* Supervisors listed in brackets: PM = Prof. Dr. Matějka, PŘ = Assoc. Prof. Řezanka, VS = Prof. Setnička